Registration Dossier

Administrative data

Description of key information

Acute Toxicity-Oral LD50 > 5000 mg/kg in rats (OECD TG 401)

Acute Toxicity-Dermal LD50 > 5000 mg/kg in rabbits (OECD TG 402)

Acute Toxicity-Inhalation LC50 > 5000 mg/m3 (OECD TG 403)

Key value for chemical safety assessment

Additional information

The acute toxicity of C9-C14 aliphatic, <2% aromatic hydrocarbon fluids has been fully evaluated.  All of the animal studies were performed in a manner similar or equivalent to currently established OECD guidelines.  Based on these data, C9-C14 aliphatic, <2% aromatic hydrocarbons have a low order of acute toxicity by the oral, dermal, and inhalation routes of exposure.

Justification for classification or non-classification

C9-C14 aliphatic, <2% aromatic hydrocarbons is minimally toxic via ingestion where the LD50 is >5000 mg/kg, via dermal exposure where the LD50 is >5000mg/kg, and by inhalation where the LC50 > 5000 mg/m3.  These findings do not warrant classification of C9-C14 aliphatic, <2% aromatic hydrocarbons under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) do not warrant classification under the Directive 67/548/EEC for dangerous substances and Directive 1999/45/EC for preparations (DSD/DPD). C9-C14 aliphatic, <2% aromatic hydrocarbons are classified under EU CLP guidelines as a Category 1 aspiration hazard based on its physical and chemical properties (hydrocarbon fluid, viscosity ≤ 20.5 mm2/s) and as an R65 aspiration hazard under the EU DSD/DPD.