Registration Dossier
Registration Dossier
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EC number: 221-660-8 | CAS number: 3179-76-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
(72-h) EC50: >1000 mg/l growth rate Scenedesmus subspicatus (read-across from 919-30-2), reliability 2
(72-h) EC50: 863 mg/l growth rate Skeletonema costatum (read-across from 919-30-2), reliability 2
NOEC: 1.3 mg/l growth rate Scenedesmus subspicatus (read-across from 919-30-2), reliability 2
NOEC: 40 mg/l growth rate Skeletonema costatum (read-across from 919-30-2), reliability 2
Key value for chemical safety assessment
- EC50 for marine water algae:
- 863 mg/L
- EC10 or NOEC for freshwater algae:
- 1.3 mg/L
- EC10 or NOEC for marine water algae:
- 40 mg/L
Additional information
There are no reliable data for the substance. However a 72-hour EC50 value of >1000 mg/l and a NOEC of 1.3 mg/l have been determined for the effects of the read-across substance, 3-aminopropyltriethoxysilane (CAS 919-30-2), on growth rate of the freshwater algae Scenedesmus subspicatus. A 72-hour EC50 of 603 mg/l and NOEC of 1.3 mg/l have been determined for effects on biomass. A 72 hour EC50 value of 863 mg/l and NOEC of 40 mg/l have also been determined for the effect of the same substance on growth rate of the marine algae Skeletonema costatum. The test substance is susceptible to very rapid hydrolysis and it is therefore likely that the test organisms were exposed to the hydrolysis products of the substance.
The studies were conducted according to an appropriate EU and ISO test methods, and in compliance with GLP, and were considered to be reliability 1 (reliable without restrictions). Read across to the registered substance is considered scientifically justified; the read across is considered to be reliability 2. Further information on read-across is given in the Aquatic toxicity endpoint summary.
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