Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-660-8 | CAS number: 3179-76-8
Endpoint summary
Administrative data
Description of key information
Additional information
No data are available for the submission substance, 3-(diethoxymethylsilyl)propylamine. However, reliable test data are available for a structurally related substance, 3-aminopropyltriethoxysilane (CAS 919-30-2).
Reliable short-term toxicity tests results are available for species of freshwater fish Danio rerio (tested as Brachydanio rerio), invertebrate (Daphnia magna) and algae Desmodesmus subspicatus (tested as Scenedesmus subspicatus). LC50or EC50values for the three organisms were >934, 331 and >1000 mg/l respectively. A NOEC of 1.3 mg/l was determined in the algal test.
Reliable short-term toxicity tests results are also available for species of marine invertebrate (Acartia tonsa) and algae (Skeletonema costatum). LC50or EC50values for the two species were 580 and 863 mg/l respectively. A 72 hour NOEC of 40 mg/l was determined in the algal test.
It is likely that the test organisms were predominantly exposed to the hydrolysis products of the substance.
Read-across justification:
The registered substance and the substance used as surrogate for read-across is part of a class of low functionality compounds which act via a non-polar narcosis mechanism of toxicity. Substances in this group include alkoxy- and chlorosilanes having secondary features that do not affect the toxicity of the substances. The silanol hydrolysis products may be susceptible to condensation reactions, see Section 1.The registered substance hydrolyses rapidly in water and therefore the selection of surrogate substance is based on log Kow of the resulting silanols and the chemical groups present in them. The side chains of the registered substance are propylamine and methyl, and the side chain of the read-across substance is also propylamine.
Additional information is given in a supporting report <REFERENCE IN PROGRESS> attached in Section 13 of the IUCLID 5 dossier.
3-(Diethoxymethylsilyl)propylamine (CAS 3179-76-8) and 3-aminopropyltriethoxysilane (CAS 919-30-2) both hydrolyse rapidly in contact with water (6 h at pH 7, 20-25⁰C, and 8.5 h at pH 7, 25⁰C respectively). The organosilicon hydrolysis products are 3-(dihydroxymethylsilyl)propylamine and 3-aminopropylsilanetriol respectively. 3-(Dihydroxymethylsilyl)propylamine and 3-aminopropylsilanetriol are structural analogues, both containing a propylamine group. The additional methyl side group in 3-(dihydroxymethylsilyl)propylamine means only that it has a slightly higher log Kow than the analogous silanetriol but both values are still very low (see below).
They also share similar physicochemical properties: high water solubility, low log Kow (-0.9 and -2.9 respectively) and low MW (135.2 and 137.2 respectively).
The other hydrolysis by-product is ethanol for both substances. Ethanol has been studied extensively in the public literature and it is not expected to be hazardous at the concentrations produced during standard environmental studies. Due to the length of the test media preparation (18 hours) and the study regimes (static or semi-static) the organisms would have been predominantly exposed to hydrolysis product, 3-aminopropyltriethoxysilaneInformation on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
