Registration Dossier
Registration Dossier
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EC number: 224-030-0 | CAS number: 4170-30-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Acceptable (pre-GLP; pre-guidelines), study containing basic data which suggests that basic scientific principles have been met. This is sufficient to judge the results reliable as a contribution to the understanding of the toxicity of this substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- none
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Crotonaldehyde
- EC Number:
- 224-030-0
- EC Name:
- Crotonaldehyde
- Cas Number:
- 4170-30-3
- Molecular formula:
- C4H6O
- IUPAC Name:
- but-2-enal
- Details on test material:
- specific gravity = 0.859
molecular weight = 70.09
boiling point = 104-106 C
solubility in water = 18% (@ 20C)
Constituent 1
Test animals / tissue source
- Species:
- human
- Details on test animals or tissues and environmental conditions:
- none
Test system
- Vehicle:
- not specified
- Controls:
- no
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: eye irritation
- Time point:
- other: 1 min
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Strong irritation reported in acute inhalation study
- Other effects:
- None
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- All of the volunteers exposed to crotonaldehyde experienced strong irritation at the eyes.
- Executive summary:
Authors reported that volunteers inhaled crotonaldehyde vapor through a mask for one minute; however, details regarding how the vapor was generated or how the concentrations were measured were not included. They measured or observed odor detection and irritation of the eyes and mucous membranes of the nose and throat (trachea). Based on the irritation effects, a threshold for crotonaldehyde irritation in humans was reported as 0.0005 mg/L (0.17 ppm).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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