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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: List VII
Author:
Smyth HF et al.
Year:
1969
Bibliographic source:
Am. Ind. Hyg. J. 30, 470-476
Reference Type:
secondary source
Title:
Fragrance raw materials monographs - Isoamly alcohol
Author:
Opdyke DLJ
Year:
1978
Bibliographic source:
Food Chem. Tox. 16, S1, 785-788
Reference Type:
secondary source
Title:
No information
Author:
RIFM
Year:
2009
Bibliographic source:
RIFM database

Materials and methods

Principles of method if other than guideline:
acc. to Smyth HF et al., Am. Ind. Hyg. Assoc. J. 23, 95, 1962
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
other: albino

Test system

Type of coverage:
open
Preparation of test site:
other: clipped
Vehicle:
other: undiluted or as a solution in water, propylene glycol or acetone
Controls:
not specified
Amount / concentration applied:
0.01 ml
Duration of treatment / exposure:
24 h
Observation period:
24 h
Number of animals:
5
Details on study design:
TEST SITE
- Area of exposure: uncovered belly

SCORING SYSTEM:
Irritation grades that ranged from 1 to 10:
grade 1 = no irritation;
2 = least visible capillary injection from the undiluted material;
6 = higher necrosis with the undiluted material;
10 = necrosis from a 0.01% solution

Results and discussion

In vivo

Results
Irritation parameter:
other: Irritation score
Basis:
other: not further specified
Time point:
other: 24 h
Score:
2
Max. score:
10
Reversibility:
no data

Any other information on results incl. tables

Irritation on uncovered rabbit belly was reported to be of grade 2 of 10,  where Grade 1 indicates no irritation and grade 2 the least visible  capillary injection from 10 µl of the undiluted chemical.

Applicant's summary and conclusion