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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: List VII
Author:
Smyth HF et al.
Year:
1969
Bibliographic source:
Am. Ind. Hyg. J. 30, 470-476
Reference Type:
secondary source
Title:
Fragrance raw materials monographs - Isoamly alcohol
Author:
Opdyke DLJ
Year:
1978
Bibliographic source:
Food Chem. Tox. 16, S1, 785-788
Reference Type:
secondary source
Title:
RIFM database
Author:
RIFM
Year:
2009

Materials and methods

Principles of method if other than guideline:
acc. Carpenter CP und Smyth Jr. HF, Am. J. Ophthal., 29, 1363, 1946
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 3-methyl-1-butanol

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: undiluted or as a solution in propylene glycol and water
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.005 - 0.5 ml
- Concentration (if solution): 1% - 100%
Duration of treatment / exposure:
one application, no washing
Observation period (in vivo):
24 h
Number of animals or in vitro replicates:
5/dose
Details on study design:
SCORING SYSTEM:
Grading according to a 10-grade series:
grade 1 = indicates at most a very small area of necrosis from 0.5 ml of undiluted test material;
grade 5 = indicates a so-called severe burn from 0.005 ml of undiluted test material;
10 = a severe burn from 0.5 ml of a 1% solution in water or propylene glycol.

Results and discussion

In vivo

Results
Irritation parameter:
other: Grading
Basis:
other: no specified
Time point:
other: 24 h
Score:
8
Max. score:
10
Reversibility:
not specified

Applicant's summary and conclusion