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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
inhalation hazard test; 8-hour exposure period
Justification for type of information:
A read-across justification is provided in the IUCLID Chapter "Assessment reports"

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Rats were exposed to a saturated solution for 8 hours and observed for 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No additional information available.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
rats were exposed to an essentially saturated solution.
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: Inhalation hazard test
Exp. duration:
8 h
Remarks on result:
other: No mortality occurred and no clinical signs were observed when rats were exposed for 8 hours to a saturated atmosphere of test substance vapours.
Mortality:
No mortality was observed in rats exposed to a substantially saturated vapor for 8 hours.
Clinical signs:
other: There were no clinical signs observed during the exposure period or observation period.
Body weight:
Exposed animals gained 53 to 82 g during the observation period.
Gross pathology:
There were no gross pathologic effects noted at the end of the observation period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No hazard is anticipated from the infrequent inhalation of substantially saturated vapor generated at room temprature under handlimg conditions.
Executive summary:

A group of 6 rats were exposed to an essentially saturated atmosphere of n-propanol for 8 hours. No significant effects were noted during or following exposure to an essentially saturated atmosphere of n-pentanol.