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EC number: 271-094-0
CAS number: 68515-51-5
A two-generation study has been undertaken
on 1,2 -Benzenedicarboxylic acid, di-C6 -10 -alkyl esters. In this study
reproductive effects occurred, seen as reduced pup survival and weights,
and a marginal delay in sexual maturity at a treatment level of 10000
ppm. Effects on reproductive organs, liver and kidney were essentially
similar in all generations and were therefore not classed as specific
reproductive effects. The NOAEL for reproductive toxicity was therefore
considered to be 3000 ppm (corresponding to a mean daily intake of 167
-776 mg/kg bw/d, mean concentration in males 235 mg/kg bw/d and mean
concentration in females 346 mg/kg bw/d). It was not possible to
identify a no effect level in this study, although at 1000 ppm
(corresponding to an intake in the range of 56 -253 mg/kg bw/d) were
confined to increased liver and kidney weights among F1 females (LOAEL
A similar study has been undertaken on a
structurally related substance,1,2
benzene dicarboxylic acid , di C9-C11 alkyl esters which has
C-chain lengths of C9, C11 compared to 1,2-Benzenedicarboxylic acid,
di-C8-10-alkyl esters C8 and C10. In this study no adverse effects upon
fertility or reproductive performance when rats were exposed to diets
containing up to 10000 ppm, corresponding to a mean daily intake of at
least 650 mg/kg/day, through two successive generations. D911P fed
through two generations had no adverse effect on the seminology
parameters investigated and no histopathological effects on the
Developmental toxicity: NOAEL - 1000 mg/kg/day
A study of developmental toxicity has been
undertaken on 1,2 -Benzenedicarboxylic acid, di-C6 -10 -alkyl esters. In
this study slight maternal effects were observed at 1000 mg/kg bw/day
indicated by slightly increased body weight gain and food consumption.
Foetal effects were confined to increases in the incidence of vestigial
supernumerary ribs at 500 and 1000 mg/kg bw/day and to a slight increase
in the incidence of retarded sternebrae at 1000 mg/kg bw/day. Both of
these findings were considered to be of a minor nature. The No Observed
Adverse Effect Level (NOAEL) for maternal toxicity was considered to be
500 mg/kg bw/day. The No Observed Adverse Effect Level (NOAEL) for
developmental toxicity was considered to be 1000 mg/kg bw/day.
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