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EC number: 271-094-0
CAS number: 68515-51-5
The acute toxicity of 1,2
-benzenedicarboxylic acid, C6 -10 alkyl esters was investigated
following dermal administration of a single dose to the rat at 2000
mg/kg according to OECD guideline 402, adopted on 24 February 1987 and
Test method B.3 "Acute Toxicity (dermal)" described in Council
Regulation (EC) No. 440/2008.
A single dose of 2000 mg/kg was administered
to a group o 5 male and 5 female animals for 24 hours. After 14 days all
animals were killed and subjected to necropsy examination. No mortality
occurred following dosing and no signs of toxicity were observed. The
body weight changes observed during the study were within the expected
range for this species and age of animals. No significant abnormalities
were found at necropsy in the animals at termination of the study. No
abnormalities were observed at the treated site. These results indicated
that the test item has no toxic effect on the rat following dermal
exposure over a 24 hour period at a level of 2000 mg/kg. The lack of
mortality demonstrated the LD50 to be greater than 2000 mg/kg.
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