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EC number: 271-094-0
CAS number: 68515-51-5
A set of genotoxicity tests has been
conducted on 1,2-Benzenedicarboxylic
acid, di-C6 -10 -alkyl esters, 1,2 -Benzenedicarboxylic acid, di-C8 -10 -
No effects were observed in a
mammalian cell gene mutation test (HPRT) for structurally related
The ability to cause chromosomal
damage in cultured human lymphocytes, following in vitro treatment
in the absence and presence of S9 metabolic activation has been
investigated with structurally related phthalates according to OECD/EU
test methods. No statistically significant increase in the incidence of
cells bearing aberrations, including or excluding gaps, was observed at
any dose level or any sampling time.
Mutagenic activity has been examined
with structurally related phthalates by assaying for the induction
mutants in mouse lymphoma L5178Y cells after in vitro treatment, in the
absence and presence of S9 metabolic activation, using a fluctuation
method according to OECD/EU test methods. No relevant increases in
mutant frequencies were observed following treatment.
Mutagenic activity has also been
examined with structurally related phthalates by the mouse Balb/3T3 cell
transformation assay. No activity was apparent even at concentrations
higher than the aqueous solubility of the phthalates.
Negative findings in various separate and
key in-vitro tests for gene mutation / mutagenicity. Supporting
information from an additional in-vitro cell transformation assay.
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