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EC number: 271-094-0
CAS number: 68515-51-5
Sub-chronic toxicity; oral: NOAEL - Males - 79.6 mg/kg/day; Females - 303.9 mg/kg/day (based on read-across)
The test substance 1,2 -Benzenedicarboxylic
acid, di-C6 -10 alkyl esters was not investigated. A 90 -day sub-chronic
oral toxicity has been undertaken on the structurally related substance
1,2 -Benzenedicarboxylic acid, di-C8 -10 -alkyl esters. The No Observed
Adverse Effect level (NOAEL) for males is considered to be a
concentration of 0.1 % in the diet, corresponding to a mean intake of
79.6 mg/kg bw/day based on hepatotoxic effects shown as histological
changes in the liver and effects on liver enzymes. For females the NOAEL
is considered to be 0.3 %, corresponding to a mean intake of 303.9 mg/kg
bw/day on the basis of increased liver and kidney weights, effects on
liver enzymes and haematological parameters.
Significant exposure to the skin is unlikely
to occur since the substance is not widely used as such. Skin contact
for workers is also unlikely to occur due to standard good hygiene
working practice. Furthermore the results of laboratory animal studies
show low acute oral and dermal toxicity. In the 28 - days repeated dose
study via oral gavage administration only minor effects at higher doses
have been observed. This intrinsic property/toxicity potential can be
extrapolated to repeated dermal route administration.
The test substance has very low vapour
pressure (< 0.001 mbar at 38°C), so the potential for the generation of
inhalable forms is low, also the use of this substance will not result
in aerosols, particles or droplets of an inhalable size, so exposure to
humans via the inhalatory route will be unlikely to occur. Furthermore
the results of laboratory animal studies show low acute oral and dermal
toxicity. In the 28 - days repeated dose study via oral gavage
administration only minor effects at higher doses have been observed.
This intrinsic property/toxicity potential can be extrapolated to
repeated inhalation route administration.
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