Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Potassium O-isobutyl dithiocarbonate
  • IUPAC name: potassium [(2-methylpropoxy)methanethioyl]sulfanide
  • Other names
EC / List no.:
235-837-2
CAS no.:
13001-46-2
Index number:
Molecular formula:
C5H9KOS2
SMILES:
[K+].CC(C)COC([S-])=S
InChI:
InChI=1S/C5H10OS2.K/c1-4(2)3-6-5(7)8;/h4H,3H2,1-2H3,(H,7,8);/q;+1/p-1
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
1
Of which contain:
4 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is a flammable solid, is harmful if swallowed, is harmful in contact with skin, causes serious eye irritation and causes skin irritation.

According to the majority of notifications provided by companies to ECHA in CLP notifications no hazards have been classified.

Breakdown of all 3 C&L notifications submitted to ECHA

Not Classified
Flam. Sol. 1 H228
Acute Tox. 4 H302
Acute Tox. 4 H312
Eye Irrit. 2 H319
Skin Irrit. 2 H315
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 1 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 - 1 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: metals, metal surface treatment products, adsorbents, polymers and extraction agents. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following activities or processes at workplace: hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting), the low energy manipulation of substances bound in materials or articles, closed, continuous processes with occasional controlled exposure, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, open transfer and processing with minerals/metals at elevated temperature, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, treatment of articles by dipping and pouring and laboratory work.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: rubber (e.g. tyres, shoes, toys) and metal (e.g. cutlery, pots, toys, jewellery).

This substance is used in the following products: polymers and extraction agents.

This substance is used in the following areas: mining and formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals, rubber products and metals.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), batch processing in synthesis or formulation with opportunity for exposure, treatment of articles by dipping and pouring, open transfer and processing with minerals/metals at elevated temperature and hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting).

Other release to the environment of this substance is likely to occur from: indoor use as processing aid and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).

This substance is used in the following products: polymers and extraction agents.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, the low energy manipulation of substances bound in materials or articles, open transfer and processing with minerals/metals at elevated temperature, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, laboratory work, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting).

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers and extraction agents.

This substance is used in the following areas: mining and formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals, rubber products and metals.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, the low energy manipulation of substances bound in materials or articles, laboratory work, open transfer and processing with minerals/metals at elevated temperature, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens) and hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting).

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and as processing aid.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, the low energy manipulation of substances bound in materials or articles, potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens), open transfer and processing with minerals/metals at elevated temperature, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting).

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: protect from moisture; keep cool; do not allow contact with water.

Response statements

In case of incident: If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If swallowed: follow instructions specified by manufacturer/supplier. If on skin: follow instructions specified by manufacturer/supplier.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • NOZIB Ltd, 67 Georgi Peyachevic Str. 67 Georgi Peyachevic Str. 1505 Sofia Bulgaria Bulgaria

Other names

  • Carbonodithioic acid, o-(2-methylpropyl) ester, potassium salt
  • PIBX
  • potassium [(2-methylpropoxy)methanethioyl]sulfanide
  • Potassium O-isobutyl dithiocarbonate
  • Isobutyl potassium xanthate
  • PIBX
  • Potassium isobutoxy xanthogenate
  • Potassium isobutyl xanthogenate

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Pellets (50%), Powder (50%) [2]
C Odour
Odourless (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Melting/freezing point

Study results
  • 2 studies submitted
  • 2 studies processed
R Melting / freezing point
202.59 - 270 °C @ 0 - 101 325 Pa [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Boiling point

Study results
  • 2 studies submitted
  • 1 study processed
R Boiling point
478.58 °C @ 0 Pa [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 1 study submitted
  • 1 study processed
R Relative density
1.24 @ 25 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Vapour pressure

Study results
  • 1 study submitted
  • 1 study processed
R Vapour pressure
0 Pa @ 25 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Log Pow
1.78 @ 25 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 2 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
724.57 - 1 512 mg/L @ 25 °C and pH 7 [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 5 studies submitted
  • 3 studies processed
R Autoflammability / self-ignition
90 - 120 °C @ 101.3 kPa [3]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 3
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Highly flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 1 study processed
R Degradation rate constant (OH radicals)
0 cm³ molecule-1 d-1 [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 4 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Study results
  • 1 study submitted
  • 1 study processed
R H - (pressure) m³/mol
4.651 Pa m³/mol @ 25 °C and 101.325 kPa [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 0 % [1]
R Water 29.9 % [1]
R Soil 70 % [1]
R Sediment 0.069 % [1]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 1.531 mg/L (1)
Intermittent releases (freshwater) 770 µg/L (1)
Marine water 2.9 mg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1 mg/L (1)
Sediment (freshwater) 6.9 mg/kg sediment dw (1)
Sediment (marine water) 690 µg/kg sediment dw (1)
Hazard for Air
Air 10 mg/m³ (1)
Hazard for Terrestrial Organism
Soil 1.97 mg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 133.3 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 18 studies submitted
  • 17 studies processed
P/RResults
LC50 (4 days) 4 - 1 000 mg/L [26]
LC50 (24 h) 10 mg/L [2]
LC100 (4 days) 180 mg/L [1]
LC100 (72 h) 300 µg/L [1]
LC100 (48 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence 2 12
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Long–term toxicity to fish

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
NOEC (30 days) 23.272 - 29.095 mg/L [2]
NOEC (8 days) 1 - 6.19 mg/L [5]

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence 2 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 8 studies submitted
  • 3 studies processed
P/RResults
EC50 (24 h) 3.6 - 3.94 mg/L [2]
LC50 (4 days) 264.477 mg/L [1]
LC50 (48 h) 123.739 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
NOEC (30 days) 13.854 - 24.401 mg/L [2]
NOEC (21 days) 20 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
EC50 (4 days) 21 - 53.385 mg/L [3]
EC50 (48 h) 230 - 1 250 mg/L [2]
NOEC (30 days) 19.665 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic plants other than algae

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC50 (14 days) 10 - 21.9 mg/L [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
EC50 (3 h) 50 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Sediment toxicity

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
LC50 (14 days) 345.118 mg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
LC50 (14 days) 345.118 mg/kg soil ww [1]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (30 days) 19.665 mg/kg soil dw [1]
EC50 (4 days) 53.385 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (14 days) 2.1 - 5.2 mg/kg soil dw [2]
EC50 (5 days) 210 - 520 µg/kg soil dw [2]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (30 days) 4 000 mg/kg diet [1]
NOEC (24 h) 4 150 - 10 267.1 mg/kg diet [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 4.6 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 4.6 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 4.6 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 4.6 mg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 36.96 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 40 mg/kg bw/day acute toxicity
Local Effects
Long-term: (DNEL) 790 µg/cm² acute toxicity
Acute /short term: (DNEL) 790 µg/cm² acute toxicity
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.3 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 2.3 mg/m³ repeated dose toxicity
Local Effects
Long-term: (DNEL) 2.3 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 2.3 mg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 18.48 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 20 mg/kg bw/day acute toxicity
Local Effects
Long-term: (DNEL) 394 µg/cm² acute toxicity
Acute /short term: (DNEL) 394 µg/cm² acute toxicity
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 10 mg/kg bw/day acute toxicity
Acute /short term: (DNEL) 10 mg/kg bw/day acute toxicity
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 3
Weight of evidence 1
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 5 studies processed
P/RResults
LD50 500 - 2 000 mg/kg bw (rat) [3]
LD50 411 - 730 mg/kg bw (mouse) [4]
M/CInterpretations of results
Moderately toxic [3]

Type of Study provided
oral
Studies with data
Key study 2 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 3 studies processed
P/RResults
LC50 (6 h) 18.18 mg/m³ air (rat) [1]
LC50 (4 h) 32.19 - 10 350 mg/m³ air (rat) [2]
LC0 (6 h) 18.2 mg/m³ air (rat) [1]
LC0 (6 h) 6 000 ppm (rat) [1]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

inhalation
Studies with data
Key study 1
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 3 studies processed
P/RResults
LD50 1 000 - 2 460 mg/kg bw (rabbit) [4]
M/CInterpretations of results
Category 4 based on GHS criteria [2]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
other routes
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: respiratory
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 10 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Study data: inhalation
  • 4 studies submitted
  • 4 studies processed
P/RResults
NOAEC (rat): 23 mg/m³ air [1]
NOAEC (mouse): 23 mg/m³ air [1]
NOAEC (dog): 23 mg/m³ air [1]
NOAEC (rabbit): 23 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEL (rabbit): 184.8 - 300 mg/kg bw/day [2]

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study
Weight of evidence 8
Other
Data waiving
no waivers
Study data: in vivo
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 1
Weight of evidence 5
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: developmental
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 3
Weight of evidence 3
Other
Data waiving
no waivers
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Neurotoxicity

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 8
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available