Registration Dossier
Registration Dossier
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EC number: 235-837-2 | CAS number: 13001-46-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The Potassium isobutyl xanthate (CAS No. 13001-46-2), the subject of this dossier) is expected to exhibit very similar toxicity to Sodium isobutyl xanthate (CAS No. 25306-75-6),)), which is also isobutyl compound.. Comparable metabolism would occur.
A 24 h EC50 of 3.6 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna.
On a molecular weight scaled basis, the EC50 would be 3.94 mg/l. (3.6 x 188.35) /172.24 =3.94 mg/l
The ECOSAR QSAR model predicts that LC50 for fresh water species would to be 123.739 mg/l therefore that the substance is effectively not toxic to Daphnid. Daphnid , 48-hr LC50 = 123.739mg/L (ppm)
The available data for marine water short-term to aquatic invertebrate are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa.
48-hr LC50(Salt water) = 12.4 mg/L (ppm)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.94 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 12.4 mg/L
Additional information
A 24 h EC50 of 3.6 mg/L has been determined for the effects of the test substance on immobilation of the Daphnia magna.
The Potassium isobutyl xanthate (CAS No. 13001-46-2), the subject of this dossier) is expected to exhibit very similar toxicity to Sodium isobutyl xanthate (CAS No. 25306-75-6),)), which is also isobutyl compound.. Comparable metabolism would occur.
On a molecular weight scaled basis, the EC50 would be 3.94 mg/l. (3.6 x 188.35) /172.24 =3.94 mg/l
The ECOSAR QSAR model predicts that LC50 for fresh water species would to be123.739 mg/l therefore that the substance is effectively not toxic to Daphnid. Daphnid , 48-hr LC50 = 123.739mg/L (ppm) The available data for marine water short-term to aquatic invertebrate are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa. 48-hr LC50(Salt water) = 12.4 mg/L (ppm)
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