Registration Dossier
Registration Dossier
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EC number: 204-625-1 | CAS number: 123-41-1
Endpoint summary
Administrative data
Description of key information
Additional information
Abiotic degradation
In general, phototransformation and hydrolysis are the main abiotic degradation pathways for a substance. Choline hydroxide is neither susceptible for phototransformation in air, water and soil nor for hydrolysis under environmental conditions. Experimental investigations are not triggered for a registration under REACH.
Biotic degradation
The read-across substance Choline chloride (CAS 67-48-1) was found to be "readily biodegradable" (BASF AG, 1984). The read-across procedure is considered as valid based on the structural and characteristical similarities to the target substance Choline hydroxide. Therefore, also Choline hydroxide is considered as "readily biodegradable" and no further investigations for biotic degradation are triggered. The substance will be degraded when entering the environmental compartment and therefore will not be persistent.
Bioaccumulation
Bioaccumulation in aquatic organisms is not expected for Choline hydroxide. The first indication for that conclusion is given by the substance specific logPow of -2.25 at 25 °C (experimentally determined, Intertek, 2013). Bioaccumulation is expected for substances possessing a partition coefficient in the range of 4.5 to 6 according to ECHA Guidance R.11, PBT Assessment. Confirmation is given by the QSAR predicted bioconcentration factor (BCF) of 3.16 L/kg (Chemservice S.A., 2013, updated 2019; updated 2022),which is far below the trigger value of 100 at which bioaccumulation is not excluded any longer.
Transport and distribution
Soil adsorption is not expected for Choline hydroxide based on the intrinsic physico-chemical properties, i.e. logPow of -2.25 (Intertek, 2013). The substance is a Quaterany Ammonium Compound (QAC), thus the soil adsorption will depend upon the cation-exchange capacity beside a variety of other parameters. However, the QSAR prediction with KOCWIN v2.00 (Koc: 1.438 L/kg; key value, Chemservice S.A., 2013, updated 2019; updated 2022) reveals that the substance possesses no strong binding capacity towards soil. Supporting information is given by a SRC PCKOWIN v1.66 prediction for the reliable read-across substance Choline chloride (CAS 67-48-1). A Koc of 2.34 was reported in the SIDS Report.
The Henry´s Law constant was determined as 2.14E-15 Pa*m³/mol at 25 °C by HENRYWIN v3.20 (Chemservice S.A., 2013, updated 2019, updated 2022). This value, as well as the key value of the Koc determination, will be taken into account for the chemical safety assessment (CSA), i.e. PNECsediment and PNECsoil derivation via the equilibrium partitioning method (EPM).
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