Registration Dossier
Registration Dossier
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EC number: 204-625-1 | CAS number: 123-41-1
Endpoint summary
Administrative data
Description of key information
Additional information
No experimental results are available concerning transport and distribution of Choline hydroxide in different environmental compartments.
Based upon the intrinsic properties of Choline hydroxide (i.e. logPow of -2.25 at 25 °C, Intertek, 2013), in accordance to REACH, no experiment is triggered in order to determine the organic carbon-normalized sorption coefficient (Koc).
As the organic-normalized sorption coefficient for soil (soil adsorption, Koc) of Choline hydroxide could not be determined with the computer program from US-EPA (EPIWIN software KOCWIN v2.00; quaternary ammonium salts are not included in the training set, therefore the prediction is outside the prediction domain), the adsorption coefficient was calculated according to Franco & Trapp (2008, 2009, 2010) to correct for the charged molecule at pH 5, 7, and 8. This pH range is representative for 98 % of the European soils. The model is not yet validated; in addition, the applicability domain is not clearly defined. Nevertheless, the Koc values of the Franco & Trapp method give a good indication on the adsorption potential of a substance depending on the pH conditions of soil. The method is based on the dissociation constant pKa and the logKow for the uncharged molecule.
The resulting Koc at pH 5-8 is 137.3 L/kg (log Koc: 2.14).
Supporting information is given in the OECD SIDS Report (2005) for the reliable read-across substance Choline chloride (CAS 67-48-1). A prediction with SRC PCKOWIN v1.66 is reported therein, resulting in a Koc 2.34 (BASF AG, 2003). Justification for the read-across procedure is given in the separate read-across statement (Chemservice S.A., 2013). Both substances, the target substance Choline hydroxide as well as the read-across substance Choline chloride possess a low soil adsorption potential. However, as the same prediction model as above had been used, this prediction can not be judged reliable for quaternary ammonium salts.
Although the Henry´s Law Constant (HLC) is no mandatory requirement under REACH, it is an important parameter for PNEC derivation using the EPM. Therefore, the value was predicted with HENRYWIN v3.20 (Chemservice S.A., 2013, updated 2019).Using the Bond Method of the computer program HENRYWIN from US-EPA a Henry´s Law Constant of 2.14E-15 Pa*m3/mol was calculated for the substance Choline hydroxide at 25 °C. The Group Method showed an “incomplete Result”.
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