Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Hydrolysis : Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Additional information
Hydrolysis :
Predicted data of target chemical and supporting weight of evidence studies for it's structurally similar read across chemicals has been reviewed to determine the effect of the test chemical in water. The studies are as mentioned below:
First study includes estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Second study includes rate of hydrolysis study was carried out at different pH 4, 5, 7 and 9 by following OECD Guide-line 111 "Hydrolysis as a Function of pH". Which was verified analytically APCI-MS. Rapid hydrolysis of this material produces methanol and trisilanols. Half life at different pH were determined to be 0.10, 0.025, 0.0090 hr respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
Third study includes the rate of hydrolysis study was carried out at different pH 4, 7 and 9 by following OECD Guide-line 111 "Hydrolysis as a Function of pH". Which was verified analytically using HPLC and ICP-AES. Rapid hydrolysis of this material produces ethanol and trisilanols. Half life at different pH were determined to be 56h, 8.4h, and 3.9 h respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Based on above information test chemical was considered as hydrolyzable i.e unstable in water.
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