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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrolysis : Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Biodegradation in water :
The biodegradability of the substance was calculated using seven different Biowin 1-7 models of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be not readily biodegradable.
Biodegradation in water and sediment :
Estimated half life of test chemical in water and sediment was 37.5 days (900 h) and 337.5 days (8100 h) respectively.
Biodegradation in soil : Biodegradation half-life of test substance in soil was estimated to be 75 days (1800 hrs).
Bioaccumualtion :
Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) fo test chemicalwas 3.162 L/kg wet-wt at 25 °C which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical was non bioaccumulative in food chain.
Waiver :
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is scientifically not necessary and does not need to be conducted because the substance has low octanol water partition coefficient and adsorption potential of substance is related to this parameter.
Additional information
Hydrolysis :
Predicted data of target chemical and supporting weight of evidence studies for it's structurally similar read across chemicals has been reviewed to determine the effect of the test chemical in water. The studies are as mentioned below:
First study includes estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Second study includes rate of hydrolysis study was carried out at different pH 4, 5, 7 and 9 by following OECD Guide-line 111 "Hydrolysis as a Function of pH". Which was verified analytically APCI-MS. Rapid hydrolysis of this material produces methanol and trisilanols. Half life at different pH were determined to be 0.10, 0.025, 0.0090 hr respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
Third study includes the rate of hydrolysis study was carried out at different pH 4, 7 and 9 by following OECD Guide-line 111 "Hydrolysis as a Function of pH". Which was verified analytically using HPLC and ICP-AES. Rapid hydrolysis of this material produces ethanol and trisilanols. Half life at different pH were determined to be 56h, 8.4h, and 3.9 h respectively. Based on values test chemical was considered as hydrolyzable i.e unstable in water.
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water was estimated to be 1.1 to 24 min, 13 to 155 min, 28 to 504 min, 0.04 to 340 min at pH 4, 5, 7, 9 respectively. Thus, based on half life values it was considered as test chemical was hydrolyzable i.e unstable in water.
Based on above information test chemical was considered as hydrolyzable i.e unstable in water.
Biodegradation in water :
Predicted data of target chemical and supporting weight of evidence studies for it's structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on biodegradation. The studies are as mentioned below:
First study includes estimation Programs Interface Suite (EPI suite, 2017) was run to predict the biodegradation potential of the test compound in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical was expected to be not readily biodegradable.
Second study includes biodegradation in water study was carried out for time period of 28 days by following the DOC-DIE AWAY TEST (EWG Guideline 79/831/EWG, Appendix V, Part C (updated edition dated July 1990), Method C.4-A. Test was carried out under aerobic condition. Benzoic acid, sodium salt was used as reference substance having > 98 % degradtion. Percentage degradation 0, 3 hours, and days 7, 14, 21, 27, 28 days were determined to be 0, 0, 47, 48, 49, 50, and 39%. Based on percentage degradation test chemical was considered as not readily biodegradable in water.
Third study includes biodegradation in water study was carried out for time period of 28 days under the aerobic condition, by following the method DOC-DIE AWAY TEST (EWG Guideline 79/831/EWG, Appendix V, Part C (updated edition dated July 1990), Method C.4-A. Activated sludge was used as test inoculum. Sodium benzoate, was used as reference substance of > 96% degradation.The DOC analysis was performed using two-point calibration in a carbon analyzer (Shimadzu). Percentage degradation of test chemical were determined to be 0, 31, 34, 33, 41, and 37% for 0, 7, 14, 21, 27, and 28 days, respectively. Thus, based on percentage degradation, test chemical was considered as not readily biodegradable in water.
The biodegradability of the substance was calculated using seven different Biowin 1-7 models of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be not readily biodegradable.
Based on above information test chemical was considered as not readily biodegradable in water.
Biodegradation in water and sediment :
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water for the test compound. If released in to the environment, 10.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low. Whearas half-life in sediment for the test compound in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment was less than 7%, indicates that test chemical was not persistent in sediment.
Biodegradation in soil :
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 83.1 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
Bioaccumulation :
Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) fo test chemicalwas 3.162 L/kg wet-wt at 25 °C which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical was non bioaccumulative in food chain.
Waiver :
In accordance with column 2 of Annex VIII of the REACH regulation, testing for this end point is scientifically not necessary and does not need to be conducted because the substance has low octanol water partition coefficient and adsorption potential of substance is related to this parameter.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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