Registration Dossier
Registration Dossier
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EC number: 253-675-0 | CAS number: 37811-72-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic invertebrates up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the chronic toxicity of isobutyl laurate (CAS 37811-72-6) to aquatic invertebrates is not available. The assessment was therefore based on a study conducted with the structurally similar substances Isopropyl myristate (CAS 110-27-0) and Fatty acids, C16-18 and C18-unsatd., iso-Bu esters (CAS 84988-79-4) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification in section 13.
The chronic toxicity of the source substance Isopropyl myristrate (CAS 110-27-0) to Daphnia magna was tested according to OECD 202 (Wierich, 1995) at 1 and 100 mg/L (nominal). After prolonged stirring, the test substance was filtered through glass fibre filter. No effects on mortality or reproduction were detected at the tested substance concentrations. Therefore, the NOELR (reproduction, 21 d) is ≥ 100 mg/L.
Similar results were recorded for the second read across study
conducted with Fatty acids, C16-18 and C18 unsaturated isobutyl esters
(CAS 84988-79-4) according to OECD guideline 202 part II (Wierich,
1995). The test organism Daphnia magna was exposed to the test substance
in a semi-static system for 21 days, at loadings of 1 and 100 mg/L. The
test solutions were prepared as water accommodated fractions (WAF). At 1
mg/L no mortality and no significant effect on reproduction was
observed. At 100 mg/L reproduction was significantly increased compared
to the control. Thus, a NOELR (21 d) ≥ 100 mg/L was determined.
Based on the available read across data chronic toxicity of isobutyl
laurate (CAS 37811-72-6) to aquatic invertebrates is not expected.
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