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EC number: 253-675-0 | CAS number: 37811-72-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic invertebrates up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of the target substance isobutyl laurate (CAS 37811-72-6) to aquatic invertebrates is not available. The assessment was therefore based on a study conducted with the structurally similar substances Isopropyl myristate (CAS 110-27-0) and Fatty acids, C16-18 and C18-unsatd., iso-Bu esters (CAS 84988-79-4) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section in 13.
The toxicity of the source substance Isopropyl myristate (CAS 110-27-0) was tested according to EU Method C.2 under GLP conditions (Küch, 1995). The test organism Daphnia magna was exposed to the test substance in a static system for 48 hours. Three different methods were used for the preparation of test solutions: 1) direct addition to 100 mg/L, 2) direct addition to 100 mg/L with removal of undissolved test substance and 3) 3-5 times saturation without separation of undissolved material. The direct addition of test material resulted in an oily film at the surface, and up to 100% immobilisation of the Daphnids. Method 2 and 3 did not lead to an oily film. Significant effects on the mobility of daphnids were not observed. Thus, the immobilisation, observed for method 1, is most probably due to physical effects caused by undissolved test substance. It can therefore be concluded that the test substance had no significant toxic effect on the test organism up to the limit of water solubility. An EC50 (48 h) of > 0.05 mg/L based on the measured substance concentration was therefore reported.
Comparable results were reported in a second key study on the acute toxicity of the source substance Fatty acids, C16-18 and C18-unsatd., iso-Bu esters (CAS 84988-79-4) to Daphnia magna was performed as a limit test according to EU guideline 92/69/EWG and GLP (Wierich, 1995). The test organism Daphnia magna was exposed to the test substance in a static system for 48 hours. Three different methods for the preparation of the test solution were applied: 1) direct addition to nominal 100 mg/L without separation of undissolved test material, 2) direct addition to nominal 100 mg/L followed by a separation of undissolved test material and 3) 3 to 5 fold saturation concentration without separation of undissolved material. Immobilisation of the daphnids was observed when the test substance was directly added to the test mediuem (method 1). The effect was to physical effects caused by the large amount of undissolved test material present in the test solution. This assumption is supported by the fact that no adverse effects were observed after separation of undissolved test material and with 3 to 5 fold saturation (method 2 and 3). It can be concluded that the test substance had no toxic effects on Daphnia magna up to the limit of water solubility. An EL50 (48 h) > 100 mg/L was reported.
Based on the results of the read across substance toxic effects of isobutyl laurate (CAS 37811-72-6) to aquatic invertebrates are not expected.
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