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EC number: 696-026-0
CAS number: 1395383-69-3
In a Guinea pig hypersensitivity test according to the Magnusson &
Kligmann procedure, all animals showed a skin sensitising effect.
re-examination of the substance description and based on the ECHA
Guidance for identification and naming of
substances under REACH, the lead registrant agreed with the other SIEF
members that the identifiers (CAS
number and EC name) used for the toxicological, ecotoxicological and
physico-chemical testing are not representative of the UVCB substance
used for the testing. Consequently,
the EC name Bis(2,3-epoxypropyl)cyclohexane-1,2-dicarboxylate and
CAS number 5493-45-8, mentioned in the testing reports and refering to a
monoconstituent substance are incorrect and should be read as
1,3-Isobenzofurandione, hexahydro-, reaction products with
epichlorohydrin with CAS number 1395383-69-3, which is representative of
the registered UVCB substance used effectively.
- skin sensitisation:
Based on the above stated assessment of the
skin sensitisation potential of bis(2,3-epoxypropyl)cyclohexane-1,2-dicarboxylate
(100% of the animals sensitized in Magnuson & Kligman test) the
substance needs to be classified as R43 (May cause sensitisation by skin
contact) according to Council Directive 2001/59/EC (28th ATP of
Directive 67/548/EEC) and Skin Sens. 1 (H317: may cause an allergic skin
reaction) according CLP (Regulation (EC) No 1272/2008 Of The European
Parliament And Of The Council) as implementation of UN-GHS in the EU.
- respiratory sensitisation:
As no data on respiratory sensitization is
available for bis(2,3-epoxypropyl)cyclohexane-1,2-dicarboxylate
a classification is not possible according to Council Directive
2001/59/EC (28th ATP of Directive 67/548/EEC) and accordingCLP
(Regulation (EC) No 1272/2008 Of The European Parliament And Of The
Council) as implementation of UN-GHS in the EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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