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EC number: 696-026-0
CAS number: 1395383-69-3
Toxicity of bis(2,3-epoxypropyl)cyclohexane-1,2-dicarboxylate to Pseudokirchneriella subcapitata in an Algal Growth Inhibition Test according to OECD 201, EU method C.3. and ISO 8692.
acute Toxicity of bis(2,3-epoxypropyl)cyclohexane-1,2-dicarboxylate to
the unicellular green algal species Pseudokirchneriella subcapitata was
determined in a static 72 hours test. The test was conducted in
accordance with OECD Guideline 201, EU Method C.3 and ISO 8692. This
study encompassed 6 treatment groups (5 dose rates of the test item:100,
32, 10, 3.2 and 1 mg test item/L (nominal), corresponding to 56, 19, 5.1,
1.8 and 0.64 mg test item/L Time Weighted Average (TWA) values,and
one control) with three replicates per test concentration and six
replicates for the control. Under the conditions of the
present study with Pseudokirchneriella subcapitata, bis(2,3-epoxypropyl)
cyclohexane-1,2-dicarboxylate reduced growth rate and inhibited the
yield of this fresh water algae species significantly at TWA
concentrations of 1.8 mg/l and higher.
The EC50 for growth rate reduction (ErC50: 0-72h) exceeded a TWA
concentration of 56 mg/l. It was expected that the ErC50 was just above
this concentration.The EC50 for yield inhibition (EyC50: 0-72h) was 18
mg/l with a 95% confidence interval ranging from 11 to 30 mg/l.The NOEC
for both growth rate reduction and yield inhibition was 0.64 mg/l based
on TWA concentrations.
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