Registration Dossier

Administrative data

Description of key information

In older studies with experimental animals it was shown that alpha-methylstyrene may cause slight skin and eye irritation.
For experimental animals there are no data available concerning respiratory irritation. In a limited study Wolf et al. (1956) reported strong eye and nasal irritation in human volunteers exposed to concentrations of >= 600 ppm (see section 7.10.3).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation:

Monsanto Co. (1972)

species: NZW rabbit

duration: 4 hrs

score: slight erythema and oedema

reversibility: fully reversible within 120 hrs

Union Carbide Co. (1975)

species: rabbit

duration: 24 hrs

score: 3 of 10

reversibility: no data

Monsanto Co. (1972)

species: NZW rabbit

duration: 24 hrs

score: 0 of 8

reversibility: fully reversible within 168 hrs

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Eye irritation:

Monsanto Co. (1972)

species: albino rabbit

duration: 24 hrs

score: 14 of 110 after 1 h

reversibility: fully reversible within 120 hrs

Union Carbide Co. (1975)

species: rabbit

duration: 24 hrs

score: 1 of 10

reversibility: no data

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In a limited study Wolf et al. (1956) reported strong eye and nasal irritation in human volunteers exposed to concentrations of >= 600 ppm. At < 10 ppm odour was not detectable, at 50 ppm was odour was detectable without mucous membrane irritation, 100 ppm were judged as strong tolerable odour and 200 ppm as strong objectionable odour, and >= 600 ppm was judges as very strong odour with strong eye and nasal irritation (see section 7.10.3). These effects occur at concentrations higher than the STEL and the OEL.


Effects on eye irritation: irritating

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Based on the avialable data classifcation as eye and respiratory irritatant (Eye Irrit. 2 & STOT SE 3) is warranted according to EU regulation 1272/2008.