Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

For alpha-methylstyrene (AMS) there are no valid studies available performed with experimental animals. In some publications, which are not assignable due to insufficient documentation, possible skin sensitizing properties of AMS in humans are described. However, these data are based on single and rare cases.

AMS gave no indication for skin irritating effects and with an acute dermal LD50 value of 14500 mg/kg the dermal penetration seems likely to be low.

In addition data for three related substances (cumene, styrene and diisopropylbenzene) are not showing a potential for skin sensitization.

Based on the widespread exposure and the long term experience with AMS in humans, it can be concluded that the substance is not a significant skin sensitizer and negates the need for any further animal testing with respect to this endpoint.


Migrated from Short description of key information:
For alpha-methylstyrene (AMS) there are no valid studies available performed with experimental animals. In some publications, which are not assignable due to insufficient documentation, possible skin sensitizing properties of AMS in humans are described. However, these data are based on single and rare cases.
AMS gave no indication for skin irritating effects and with an acute dermal LD50 value of 14500 mg/kg the dermal penetration seems likely to be low.
In addition data for three related substances (cumene, styrene and diisopropylbenzene) are not showing a potential for skin sensitization.

Based on the widespread exposure and the long term experience with AMS in humans, it can be concluded that the substance is not a significant skin sensitizer and negates the need for any further animal testing with respect to this endpoint.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
There are no data available.

Justification for classification or non-classification