Registration Dossier
Registration Dossier
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EC number: 212-782-2 | CAS number: 868-77-9
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Morphological Changes of Rabbit|Skin by Application of Dentin Primer
- Author:
- Manabe A., Hasegawa T., Chigira H., Itoh K., Wakumoto S.,|Nakayama S., Tachikawa T. (1990)
- Year:
- 1 990
- Bibliographic source:
- Dent. Mater. J. 9(2):|147-152 (1990)
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxyethyl methacrylate
- EC Number:
- 212-782-2
- EC Name:
- 2-hydroxyethyl methacrylate
- Cas Number:
- 868-77-9
- Molecular formula:
- C6H10O3
- IUPAC Name:
- 2-hydroxyethyl methacrylate
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- twice a day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
30 ul, aqueous solution of 35 wt%
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 7 days
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No obvious morphological changes were recognized in the
shaved skin of rabbits after repeated application of HEMA.
HEMA caused insignificant irritation to the dermis.
Histopathology of skin only.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
