Registration Dossier

Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
endocrine system modulation
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Screening test.

Data source

Referenceopen allclose all

Title:
No information
Author:
Bolger R, Wiese TE, Evrin K, Nestich S, Checovich W (1998) Rapid screening of environmental chemicals for estrogen receptor binding capacity. Environ Health Perspect 106: 551-557
Title:
No information
Author:
Hashimoto Y, Nakamura M (2000) Estrogenic activity of dental materials and bisphenol-A related chemicals in vitro. Dent. Mater. J. 19(3): 245-262
Title:
No information
Author:
Nishihara T, Nishikawa J, Kanayama T, Dakeyama F, Saito K, Imagawa M, Takatori S, Kitagawa Y, Hori S, Utsumi H (2000) Estrogenic activities of 517 chemicals by yeast two-hybrid assay. J. Health Sci. 46(4): 282-298
Title:
No information
Author:
Nishikawa J, Saito K, Goto J, Dakeyama F, Matuso M, Nishihara T (1999) New screening chemicals with hormonal methods for activities using interaction of nuclear hormone receptor with coactivator. Toxicol Appl Pharmacol 154: 76-83
Title:
No information
Author:
Villalobos M, Olea N, Brotons JA, Olea-Serrano MF, Ruiz de Almodovar JM (1995) The E-Screen assay: a comparison of different MCF-7 cell stocks. Environ Health Perspect 103: 844-850

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Administration / exposure

Details on study design:
Type: other: estrogenic activity

Results and discussion

Any other information on results incl. tables

RS-Freetext:
2-HEMA did not show any estrogenic activity at concentrations between  10E-7 and 10E-3 M.

Applicant's summary and conclusion