Registration Dossier

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Use of|Mathematical Models in the Study of Structure-Toxicity|Relationship of Dental Compounds: I. Esters of Acrylic and|Methacrylic Acids;
Author:
Lawrence W.H., Bass G.E., Purcell W.P., Autian J.;
Year:
1972
Bibliographic source:
J. Dental. Res. 51(2): 526-535
Reference Type:
publication
Title:
Toxicological and|Pharmacological Actions of Methacrylate Monomers I: Effects|on Isolated, Perfused Rabbit Heart
Author:
Mir G.N., Lawrence W.H., Autian J.
Year:
1973
Bibliographic source:
Journal Pharmaceutical|Sciences 62: 778-782

Materials and methods

Principles of method if other than guideline:
other: no data
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Density: 1.064 g/cm3 at 25 degree C

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
528 mg/kg bw
Remarks on result:
other: Reported as 0.497 ml/kg

Applicant's summary and conclusion