Registration Dossier

Environmental fate & pathways

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Administrative data

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Manufacturing of Niacinamide and use may result in its release to the environment through various waste streams. Nicotinamide (vitamin B3) is a precursor of the coenzymes NAD and NADP. If released to air, an estimated vapor pressure of 0.00045 Pa at 25 °C indicates nicotinamide will exist in both the vapor and particulate phases in the atmosphere. Particulate-phase nicotinamide will be removed from the atmosphere by wet or dry deposition. If released to soil, nicotinamide is expected to have very high mobility based upon an estimated Koc of 15. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 2.9E-12 atm-cu m/mole. Nicotinamide was determined to be readily biodegradable in an aerobic screening test. If released into water, nicotinamide is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. Hydrolysis is not expected to be an important environmental fate process since amides hydrolyze slowly under environmental conditions. An estimated BCF of 3.162 suggests that there is practically no potential for bioconcentration in aquatic organisms.