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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well reported literature study, but non-standard design. Findings are consistent with those in other similar studies.

Data source

Reference
Reference Type:
publication
Title:
Effects of chromium compounds on the respiratory system. Part 4. Long-term inhalation of chromic acid mist in electroplating to ICR female mice
Author:
Adachi S, Yoshimura H, Katayama H, Takemoto K
Year:
1986
Bibliographic source:
Japanese Journal of Industrial Health 28(4): 283-287

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Respiratory tract toxicity was investigated following repeated inhalation exposure to chromic acid mist for two 30 minute periods a week for 6-12 months.
GLP compliance:
no
Remarks:
published literature study
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Mice were exposed to aqueous solutions of chromium trioxide (chromic acid (mist)). No further details are given.

Test animals

Species:
mouse
Strain:
ICR
Sex:
female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
other: water; chromic acid is aqueous chromium trioxide
Remarks on MMAD:
MMAD / GSD: 85% of the mist particles are reported to have been <5 µm diameter and 97% were <10 µm diameter.
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
Mice were exposed for two periods of 30 minutes per week, for 6-12 months.
Frequency of treatment:
Mice were exposed for two periods of 30 minutes per week, for 6-12 months.
No. of animals per sex per dose:
Exposed animals were terminated at 6-9 months (15 mice), 10-14 months (14 mice) and all remaining animals at 15-18 months (19 mice). Control
animals (10) were terminated at 12 and 18 months.
Control animals:
yes, concurrent no treatment

Results and discussion

Effect levels

Dose descriptor:
LOAEC
Effect level:
3.63 mg/m³ air
Sex:
female
Basis for effect level:
other: Irritant and corrosive effects were observed at 3.63 mg/m³ - the only exposure concentration evaluated

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Irritant and corrosive effects in the respiratory tract (perforated nasal septum, tracheal and bronchial epithelial hyperplasia, emphysema) occurred in treated animals.

Applicant's summary and conclusion

Conclusions:
Exposure to chromic acid mist at the exposure level equivalent to 3.63 mg Cr/m³ for 6-12 months was found to induce changes consistent with irritation and corrosion in the respiratory tract of female mice.
Executive summary:

Female ICR mice were exposed to chromic acid mist at a concentration equivalent to 3.63 mg Cr/m³ for two 30 -minute periods a week for 6 -12 months. The study focused on local effects only. Exposure was found to induce changes consisitent with irritation and corrosion in the respiratory tract.