Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The EU RAR reports the results of a number of studies of different design, however the results are consistent.

Data source

Reference
Reference Type:
review article or handbook
Title:
European Union Risk Assessment Report: chromium trioxide, sodium chromate, sodium dichromate, ammonium dichromate and potassium dichromate
Author:
European Chemicals Bureau
Year:
2005
Bibliographic source:
3rd. Priority List; Volume 53

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The EU RAR reports the results of a number of eye irritation studies of different design.
GLP compliance:
no
Remarks:
published studies, predate GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
The reviewed studies were performed with sodium chromate and potassium dichromate.

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: undiluted / neutralised
Controls:
no
Duration of treatment / exposure:
Various
Observation period (in vivo):
Various
Number of animals or in vitro replicates:
Not stated

Results and discussion

Any other information on results incl. tables

A single administration of neutralised sodium chromate solution was not irritant to the rabbit eye. In contrast, repeated administration of potassium dichromate in powder form daily for 7 days caused severe irritation including necrosis of the conjunctivae and ulceration of the cornea.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
It is concluded that the water soluble chromium (VI) compounds are likley to be eye irritants.
Executive summary:

The results of animal experiments indicate that water-soluble Cr (VI) compounds are likely to be eye irritants as a consequence of their low pH.