Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The EU RAR reports the results of a number of studies of various designs achieving comparable results.

Data source

Reference
Reference Type:
review article or handbook
Title:
European Union Risk Assessment Report: chromium trioxide, sodium chromate, sodium dichromate, ammonium dichromate and potassium dichromate
Author:
European Chemicals Bureau
Year:
2005
Bibliographic source:
3rd. Priority List; Volume 53

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The review summarises the results of a number of studies of skin irritation performed in different species and using various, largely non-standard methods.
GLP compliance:
no
Remarks:
published studies, predating GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
Studies were performed using sodium chromate, sodium dichromate, potassium dichromate, and chromium trioxide.

Test animals

Species:
other: various
Strain:
other: various

Test system

Type of coverage:
other: various
Preparation of test site:
other: various
Vehicle:
other: undiluted or saline
Controls:
not specified
Duration of treatment / exposure:
The review summarises the results of a number of studies of skin irritation performed in different species and using various non-standard methods
Observation period:
Various
Number of animals:
Various

Results and discussion

Any other information on results incl. tables

All of the water-soluble Cr (VI) compounds were found to be skin irritants in the studies sumamrised in this review. Chromium (VI) trioxide is considered to be corrosive as a consequence of its low pH.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The findings of a number of non-standard studies in various animal species indicate that water-soluble Cr (VI) compounds sodium chromate, sodium dichromate and potassium dichromate are likely to be skin irritants.
Executive summary:

The EU RAR summarises the results of a number of non-standard studies in animals which indicate that the water-soluble Cr (VI) compounds sodium chromate, sodium dichromate and potassium dichromate are likely to be skin irritants. Experience from occupational exposure to these compounds indicates severe dermal irritation / corrosivity.