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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
No details of a guideline and only limited details of the method are given in this brief report. A group of 5 rats was exposed to the saturated vapour for 7 hours.
GLP compliance:
no
Test type:
other:

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichloro(methyl)(phenyl)silane
EC Number:
205-746-2
EC Name:
Dichloro(methyl)(phenyl)silane
Cas Number:
149-74-6
Molecular formula:
C7H8Cl2Si
IUPAC Name:
dichloro(methyl)(phenyl)silane

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
7 h
Concentrations:
Unstated. Said to be saturated. Room temperature 27 deg C. No further details given.
No. of animals per sex per dose:
5 (sex not stated)
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC100
Effect level:
other: atmosphere said to be saturated
Based on:
test mat.
Exp. duration:
7 h
Remarks on result:
other: death of 5/5

Any other information on results incl. tables

One animal died during the exposure. The other 4 died within one hour post-exposure.

Nasal irritation within 20 minutes followed by marked irritation to eyes.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
A very limited summary of non-guideline, non-GLP study, recorded the deaths of all five rats during or within 1 h of a 7 h exposure to an atmosphere said to be saturated with the test material.