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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1969
Report Date:
1969

Materials and methods

Principles of method if other than guideline:
No details of a guideline and only limited details of the method are given in this brief report. A group of 5 rats was exposed to the saturated vapour for 7 hours.
GLP compliance:
no
Test type:
other:

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
7 h
Concentrations:
Unstated. Said to be saturated. Room temperature 27 deg C. No further details given.
No. of animals per sex per dose:
5 (sex not stated)
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC100
Effect level:
other: atmosphere said to be saturated
Based on:
test mat.
Exp. duration:
7 h
Remarks on result:
other: death of 5/5

Any other information on results incl. tables

One animal died during the exposure. The other 4 died within one hour post-exposure.

Nasal irritation within 20 minutes followed by marked irritation to eyes.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
A very limited summary of non-guideline, non-GLP study, recorded the deaths of all five rats during or within 1 h of a 7 h exposure to an atmosphere said to be saturated with the test material.