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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1969
Report Date:
1969

Materials and methods

Principles of method if other than guideline:
No guideline is specified and only limited details of the method are given in this brief report.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
no details
Observation period (in vivo):
no details
Number of animals or in vitro replicates:
no details

Results and discussion

In vivo

Results
Irritation parameter:
other: severe pain and tissue damage
Time point:
other: not stated

Any other information on results incl. tables

Application of an unspecified volume of the neat material caused severe pain and tissue damage resulting in loss of both eyes. The eyes were washed and unwashed, no difference is recorded as to the effect of this treatment.

Applicant's summary and conclusion

Conclusions:
A brief report of a possibly limited study found that the neat material (volume unspecified) applied to rabbit eyes caused severe pain and tissue damage resulting in the loss of both eyes.