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EC number: 205-746-2
CAS number: 149-74-6
The key acute oral study was conducted according to OECD 423 (Acute
Toxic Class method), giving an LD50 for dichloro(methyl)(phenyl)silane
male and female rats in the range > 200 - < 2000 mg/kg when dosed in
corn oil ( LPT Laboratory of Pharmacology and Toxicology, 2002).
Clinical signs observed included reduced motility, ataxia, reduced
muscle tone, dyspnoea, lateral position and ptosis at the higher dose
level. At the lower dose level no animals showed any signs of systemic
toxicity. No abnormalities were found at macroscopic post mortem
examination of the animals. No microscopic examination of tissues was
There are no inhalation or dermal acute toxicity studies for
The key oral study was selected as the
only available reliable study. It was a GLP-compliant, guideline study
In a non-guideline, non-GLP acute inhalation study, the deaths of all
five rats during or within 1 h of a 7 h exposure to an atmosphere
saturated with the test material were reported (Dow Corning Corporation,
On the basis of the available information,
dichloro(methyl)(phenyl)silane is not classified for acute toxicity
according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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