Registration Dossier

Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only short summary available; too few data for assessment

Data source

Reference
Reference Type:
publication
Title:
Effect of Chlorinated Alkanes on Hepatic Triglyceride Secretion
Author:
Selan, F. M. and Evans, M. A.
Year:
1987
Bibliographic source:
Res. Commun. Chem. in Pathol. Pharmacol. 55, 249- 269

Materials and methods

Principles of method if other than guideline:
The effect of a series of monochloroalkanes on hepatic triglyceride secretion was investigated in male Swiss Webster mice and Spague Dawley rats in vitro and in vivo.
GLP compliance:
not specified
Type of method:
other: in vivo and in vitro
Endpoint addressed:
basic toxicokinetics

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1-chlorobutane

Test animals

Species:
other: rat and mouse
Strain:
other: SD rats and Swiss Webster mice
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
single treatment
Frequency of treatment:
once
Post exposure period:
no data
No. of animals per sex per dose:
no data
Control animals:
yes, concurrent vehicle

Results and discussion

Details on results:
1-Chlorobutane produced a dose-related decrease in serum triglyceride levels at 2 hours after administration of different doses in corn oil (0.1 ml/kg bw). The dose necessary to produce a 50% decrease in in vivo triglyceride secretion was 43.9 mmol/kg (4.1 g/kg). The n-buyl chloride concentration required to produce a 50% decrease in triglyceride secretion by isolated hepatocytes was 24.7 mM (23 mg/mL).

Applicant's summary and conclusion