Registration Dossier

Administrative data

Endpoint:
immunotoxicity: short-term oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only short abstract; insufficient for assessment to few data available

Data source

Reference
Reference Type:
publication
Title:
Hygienische Begründung für den zulässigen Gehalt Benzylchlorids und Butylchlorids in den Gewässern
Author:
Rudnev, M. I. et al.
Year:
1979
Bibliographic source:
Gig. Sanit. 3, 11-15

Materials and methods

Principles of method if other than guideline:
Immunotoxicity was evaluated in albino rats.
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Chlorbutyl

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
30 days
Frequency of treatment:
once daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.00022, 0.0022, 0.022 and 110 mg/kg bw
Basis:
nominal conc.
No. of animals per sex per dose:
10
Control animals:
yes, concurrent vehicle

Results and discussion

Results of examinations

Details on results:
 

Any other information on results incl. tables

The authors interpreted the results as indication of possible dose dependent sensitization reactions. Since the criteria of the assessment are not documented, the study is difficult to evaluate.

Applicant's summary and conclusion