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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: too few data for assessment

Data source

Reference
Reference Type:
publication
Title:
Studies on Chemical Carcinogens. XXIII. A Simple Method for Characterization of the Alkylating Ability of Compounds by using 4-(p-Nitrobenzyl)pyridine
Author:
Kawazoe, Y. et al.
Year:
1982
Bibliographic source:
Chem. Pharm. Bull. 30, 2077-2086

Materials and methods

Type of study / information:
alkylating potency
Principles of method if other than guideline:
Alkylating agents were characterized by measuring the reaction selectivity towards 4-(p-nitrobenzyl)pyridine (NBP) in acetone containing phosphate buffer.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

In this solution n-butyl chloride had a half life of 90 hours and a selectivity constant of 1.52, demonstrating a low reactivity under the reaction conditions.

Applicant's summary and conclusion