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EC number: 905-588-0
CAS number: -
Exposure to up to 500 ppm ethyl benzene vapour for 28-d did not affect the humoral component of the rat immune system.
The potential impact of ethyl benzene (EB)
on humoral immune function in female SD rats exposed to 0, 25, 125 and
500 ppm EB for 28-d has been assessed using a splenic antibody cell
plaque-forming assay (AFC) following sensitisation of the animals to
sheep red blood cells. The study was OPPTS 870.7800 compliant, with the
results providing a measure of the effect of ethylbenzene on humoral
immune responses. The results showed that spleen and thymus weights from
exposed animals were unremarkable, with no treatment-related effects on
spleen cell number or IgM AFC responses in red blood cell-sensitised
animals. In contrast spleen and thymus weights, together with specific
and total IgM AFC, were clearly and significantly reduced after
cyclophosphamide treatment (positive control substance). The results
demonstrate that sub-acute exposure to up to 500 ppm ethyl benzene
vapour for 28 -d was without effect on the humoral component of the rat
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