Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 905-588-0
CAS number: -
The auditory function of 30 medical
laboratory workers (15 males and 15 females) who had been exposed to a
mixture of xylene isomers was compared to that of 30 non-exposed workers
matched for gender, age, and educational level. Participants of both
groups were not exposed to noise levels above 85 dBA time-weighted
average. All participants were evaluated in a sound-treated room, using
a comprehensive audiological test battery, which included measures of
peripheral and central auditory function. Xylene-exposed participants
were evaluated before their shift commenced, approximately 16 hours
after their last exposure. Airborne xylene samples were collected at 11
different work stations throughout the 9 histology laboratories studied.
The mean airborne xylene concentration was 36.5 mg/m3. Urine samples
were collected from each xylene-exposed worker and the methyl hippuric
acid concentration was determined. The mean concentration of methyl
hippuric acid was 216.3 mg per gram of creatinine in urine. Noise
dosimetry was also performed on each xylene exposed subject and the mean
daily noise exposure level was 72.9 dBA. The xylene-exposed participants
showed significantly worse pure-tone thresholds in comparison with the
nonexposed participants. The xylene-exposed participants demonstrated
significantly worse results than the control group participants for the
pitch pattern sequence test, dichotic digit test, speech recognition in
noise test, and the auditory brainstem response (absolute and interpeak
latencies). A significant correlation between the concentrations of
methyl hippuric acid in urine and binaural average hearing level (2 to
8kHz) was found in xylene-exposed workers. Also, participants with high
cumulative dose of xylene exposure presented with poorer test results
than participants with low cumulative dose of xylene exposure. The
results of the study provide limited evidence that xylene may induce a
decrement in pure-tone hearing thresholds as well as in some central
auditory nervous system functions such as temporal ordering, binaural
integration, and speech perception in noise, but dose-response
relationships were not observed between xylene exposure and the outcomes
for central auditory nervous system function. It could not be determined
whether the adverse effects are acute or permanent. Outer hair cell
dysfunction is not indicated by the nonsignificant differences in DPOAE
amplitudes between xylene-exposed and nonexposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
За да гарантираме, че се възползвате максимално от функциите на нашия уебсайт, сме въвели „бисквитки“.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again