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EC number: 905-588-0
CAS number: -
and female Crl:CD(SD)IGS BR rats were exposed by inhalation to 0, 25,
100 or 500 ppm ethylbenzene for 6 hr/day throughout the 2-generation
study except for females between lactation days 1 and 4 when the dose
was administered in corn oil by oral gavage at dose levels of 26, 90 or
342 mg/kg/day (to provide similar maternal blood (AUC) as provided by
500 ppm ethylbenzene, the males of both generations showed reduced body
weight gain and increased liver and kidney weights whilst only liver
weights were affected in females. As
the reduced body weight gain in the 500 ppm males was transient and
there were no histopathological changes associated with the increased
organ weights in the 500 ppm males and females, these changes were
considered not to be adverse. Therefore,
for parental systemic toxicity the NOEC was considered to be 100 ppm and
the NOAEC 500 ppm. There were no adverse effects of ethylbenzene on
reproductive performance in either generation. Neither were there any
effects of treatment on spermatogenic endpoints, ovarian follicle
counts, reproductive organ weights or macroscopic pathology. The
NOAEC for reproductive toxicity and offspring development was 500 ppm
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