Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-784-6 | CAS number: 15687-27-1
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- no full article, but short communication; some details missing, e.g. test material identification (only name given)
Data source
Reference
- Reference Type:
- publication
- Title:
- Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study
- Author:
- Fernandes D, Schnell S, Porte C
- Year:
- 2 011
- Bibliographic source:
- Marine Pollution Bulletin 62: 2250–2253
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In vitro interference of drugs with key enzymatic activities—C17,20-lyase and CYP11beta-involved in the synthesis of active androgens in gonads of male carp
- GLP compliance:
- no
Test material
Constituent 1
- Specific details on test material used for the study:
- only name given, but no further details (CAS number, purity, source)
Results and discussion
Any other information on results incl. tables
- CYP17: no effect of ibuprofen (1mM) upon C17,20-lyase (CYP17)
- CYP11b: low inhibitory effect (ca. 20% inhibition) of ibuprofen (1 mM)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
