Registration Dossier
Registration Dossier
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EC number: 239-784-6 | CAS number: 15687-27-1
Neurotoxicity
Administrative data
Description of key information
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In a study the electrical activity measurements using micro-electrode array (MEA) chips were evaluated to see whether they are a reliable, accurate, and robust endpoint for the detection of neurotoxicity. Ibuprofen was chosen as a non-neurotoxic substance. The micro-electrode array (MEA) assay consists of a culture chamber into which an integrated array of micro-electrodes is capable of measuring extracellular electrophysiology (spikes and bursts) from electro-active tissues. In this case neural networks were used, which were prepared from fetal day 18 rats. Experiments were carried from 25 to 54 days in vitro (DIV), when neuronal networks are mature. Each substance was tested at least three times and using neuronal networks from different neuronal isolations. The test substance had no significant effect on the mean firing rate of the neural networks.
In the second study, the effect on behavior of male mice that were previously exposed during a brain growth spurt period was assessed. In this study, male NMRI mice pups were exposed to doses of 6, 30 and 150 mg/kg bw/day on postnatal day 10 (in 2 subcutaneous injections, 4h apart). At 2 months of age the animals were subjected to a spontaneous behavioral test, that consisted of locomotion, rearing and total activity testing. None of the mice that were exposed differed significantly from the control considering the parameters assessed.
Justification for classification or non-classification
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