Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Toxicity of propylene oxide determined on experimental animals
Author:
Rowe VK, Hollingsworth RL, Oyen F, Mccollister DD, Spencer HC
Year:
1956
Bibliographic source:
AMA Arch Ind Health 13(3):228-36

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity in Rodents)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
5 days/week for 24 days

Results and discussion

Results of examinations

Details on results:
impaired growth, gastric irritation and slight liver damage

Effect levels

Dose descriptor:
LOEL
Effect level:
300 mg/kg bw/day (nominal)
Based on:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion