Registration Dossier

Administrative data

Endpoint:
in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Genotoxic effects of ethylene oxide and propylene oxide in mouse bone marrow cells
Author:
Farooqi Z, Tornqvist M, Ehrenberg L, Natarajan AT
Year:
1993
Bibliographic source:
Mutat Res 288(2):223-8

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 483 (Mammalian Spermatogonial Chromosome Aberration Test)
GLP compliance:
not specified
Type of assay:
other: bone marrow

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse

Results and discussion

Test results
Genotoxicity:
positive
Toxicity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): positive