Registration Dossier

Administrative data

Endpoint:
developmental toxicity
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Teratogenic study of ethylene and propylene oxide and n-Butyl Acetate
Author:
Hackett PL, Brown MG, Buschbom RL, Clark ML, Miller RA, Music RL, Rowe SE, Schirmer RE, Sikov MR.
Year:
1982
Bibliographic source:
Department of Health and Human Services (US), Centers for Disease Control & Prevention; NIOSH (National Institute for Occupational Safety and Health)

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 414 (Prenatal Developmental Toxicity Study)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
LOEC
Effect level:
1 188 mg/m³ air
Based on:
test mat.
Basis for effect level:
other: developmental toxicity

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion