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EC number: 601-409-2
CAS number: 116020-44-1
All animals survived the observation period. Body weight development of
the treated rabbits was inconspicuous.
No signs of clinical toxicity were detected. No signs of irritation were
observed at the cornea or iris. All animals showed redness (score 1) and
discharge (score 1) one hour after instillation of the test material. No
abnormalities were detected in the untreated eyes.
of all animals (mean score):
The purpose of this primary eye irritation assay was to provide
information on possible health hazards in case of acute eye contact with
a test material and serve as a rational basis for risk assessment to the
eye irritating potential of the test item in man.
To test for eye irritation a test according to the OECD-Guidelines for
Testing of Chemicals No. 405, the annex to Directive 92/69 EEC, and the
recommendations of DRAIZE (1959) was performed.
No signs of irritation were observed at the cornea or iris. One hour and
24 hours after treatment, the conjunctivae showed redness (score 1) in
two animals. Furthermore, discharge (score 1) was seen one hour after
treatment. Thereafter no signs of irritation were observed. The
untreated eyes were unchanged.
No eye irritating potential could be detected, thus the test material
should not be classified as eye irritant according to EU Regulation No.
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