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EC number: 601-409-2
CAS number: 116020-44-1
The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian cells thus providing information on possible health hazards for the test material and serve as a rational basis for risk assessment to the genotoxic potential of the test item in man.
In this study the clastogenic potential of the test material was evaluated by examining its effects on the chromosomes of CHO cells, cultured in vitro and treated in the absence and presence of a rat liver metabolising system (S-9). The test methodology in this study is in accordance with current literature and complies with the OECD Guideline 473 (1997).
Precipitation of the test material was observed at concentrations larger or equal to 81.9 µg/mL. The test material did not induce structural chromosome aberrations when tested at, or very close to, its limit of cytotoxicity following 24 hour treatment in the absence and presence of S9. No treatment-related increase of endoreduplications or polyploid cells was observed.
i.e. neither structural nor numerical aberrations were detected.
In conclusion, treatment of V79 cell cultures with the test material, did not increase the proportion of cells with aberrant chromosomes, thus the test material was not clastogenic in this in vitro test system.
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