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EC number: 601-409-2
CAS number: 116020-44-1
The purpose of this assay was to identify the aquatic toxicity potential the test material in algea to provide a rational basis for hazard estimation for the test item in aquatic environments.
The influence of the test material on the growth and growth rate of the green algae species Desmodesmus subspicatus was tested. The study design included one control and one test material group with six replicates, each containing about 100 rnL reconstituted water or test medium and 10,000 cells/mL at the start of the experimental phase. The algae were exposed to a filtrate of nominal 100 mg/L and the study was performed as a limit test in an open static test system. The growth was calculated after 24, 48, and 72 hours exposure in the test medium.
The analysis of the saturated aqueous preparation revealed that the water solubility of the test material in reconstituted water was < 0.06 mg/L. The test material concentration in the aqueous medium could not be quantified since it was below the level of detection. For the test material, the following EC50 values and no effect concentration for Desmodesmus subspicatus were determined:
72 h EC50 > 100 mg/L (nominal)
72 h NOEC > 100 mg/L (nominal)
An aqueous preparation of 100 mg/L (nominal) of the test material revealed no toxic effect in the test system. The 72 hours EC50 exceeded the maximum solubility of the test material in reconstituted water.
For this endpoint, adequate information is provided from a read across
to a GLP compliant OECD TG 202 study performed for a structural similar
compound that shows a similar phys-chem. profile. The study performed
for this compound gives a NOEC of 100 mg/L (nominal).
for read across
of read across:one-to-one
almost identical physicochemical profile
same response in biological systems relevant for the endpoint as shown
surrogate (CAS 96624-52-1)
< 0.02 mg/L
Fish Acute Toxicity
LC50 (96h) > 100 mg/L
below 2000 (639)
below 2000 (56)
NOEC (> 100 mg/L) observed for the surrogate is used as read across
reference for the test item.
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