Registration Dossier
Registration Dossier
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EC number: 405-490-3 | CAS number: 613-62-7 BENZYL-2-NAPHTHYLETHER; BETA-NAPHTHYLBENZYLETHER (BON); BNE; BON; NIPAFAX BNE; SENSLON-50; ZO-1
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study submitted in the ELINCS notification dossier.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 415 [One-Generation Reproduction Toxicity Study (before 9 October 2017)]
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 2-(phenylmethoxy)naphthalene
- EC Number:
- 405-490-3
- EC Name:
- 2-(phenylmethoxy)naphthalene
- Cas Number:
- 613-62-7
- Molecular formula:
- C17H14O
- IUPAC Name:
- 2-(benzyloxy)naphthalene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- males: 70 days before mating and during gestation
females: 14 days before mating, during gestation and 2 weeks of lactating period. - Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
600 ppm
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
3000 ppm
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
15000 ppm
Basis:
nominal in diet
- No. of animals per sex per dose:
- 25
- Control animals:
- yes, concurrent no treatment
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Increase of food consumption in amles of groups 3 and 4 before mating. In females, decrease of the food consumption and of the body weight before and during gestation, in groups 3 and 4.
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- Increase of food consumption in amles of groups 3 and 4 before mating. In females, decrease of the food consumption and of the body weight before and during gestation, in groups 3 and 4.
Reproductive function / performance (P0)
- Reproductive performance:
- effects observed, treatment-related
- Description (incidence and severity):
- No effects on conception rate and on gestation duration. Decrease of the implantation incidence and loss after implantationin the group 4. Litter size reduced in group 4, also observed in the group 3 but the variation is within the historical control rang
Details on results (P0)
Groups 1 and 3: 24
Groups 2 and 4: 25
Effect levels (P0)
- Dose descriptor:
- NOEC
- Effect level:
- 600 ppm
- Based on:
- not specified
- Sex:
- male/female
- Basis for effect level:
- other: Corresponding to 43.6 mg/kg/day (males) and 71.1 mg/kg/day (females)
Results: F1 generation
General toxicity (F1)
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Decrease of mean body weight in groups 3 and 4 after 21 days of lactation.
- Gross pathological findings:
- no effects observed
Effect levels (F1)
- Dose descriptor:
- NOEC
- Generation:
- F1
- Effect level:
- 600 ppm
- Based on:
- not specified
- Sex:
- male/female
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The observed effects on the offsprings are supposed to be the consequence of the effects on the P generation.
- Executive summary:
A 1-generation study has been performed in the Wistar rat exposed to the substance at concentrations of 600, 3000 or 15000 ppm in the diet.
Effects on the food consumption and on the body weight of the females were observed at 3000 and 15000 ppm. At 15000 ppm, reduced implantation incidence, loss after implantation, reduced litter size were also observed.
In the offsprings of the groups treated with 3000 and 15000 ppm, a reduced mean body weight was seen on day 21 of lactation.
The NOEC is 600 ppm in both generations. The observed effects on the offsprings are supposed to be the consequence of the effects on the P generation.
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