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EC number: 230-896-0
CAS number: 7360-38-5
In accordance with Annex IX, column 2 (9.4) of Regulation (EC) No. 1907/2006, testing for toxicity to soil macroorganisms is not required since direct and indirect exposure of the soil compartment is unlikely. Furthermore, Propane-1,2,3-triyl 2-ethylhexanoate is unlikely to pose a risk for terrestrial organisms considering the low toxicity as expected for this substance. Therefore, no tests on terrestrial macroorganisms are provided.
Intrinsic properties and fate/ exposure
Propane-1,2,3-triyl 2-ethylhexanoate (CAS No. 7360-38-5) is readily
biodegradable (85% O2 consumption in 28 days; METI, 2002). According to
the Guidance on information requirements and chemical safety assessment,
Chapter R.7b, readily biodegradable substances can be expected to
undergo rapid and ultimate degradation in most environments, including
biological Sewage Treatment Plants (STPs) (ECHA, 2017b). Therefore,
after passing through conventional STPs, only low concentrations of
these substances are likely to be (if at all) released into the
Furthermore, the substance exhibits a log Koc value of 6.28 and is
poorly water soluble (< 0.05 mg/L measured in aqua dest).The Guidance on
information requirements and chemical safety assessment, Chapter R.7b
(ECHA, 2017b) states that once insoluble chemicals enter a standard STP,
they will be extensively removed in the primary settling tank and fat
trap and thus, only limited amounts will get in contact with activated
sludge organisms. Nevertheless, once this contact takes place, these
substances are expected to be removed from the water column to a
significant degree by adsorption to sewage sludge (Guidance on
information requirements and chemical safety assessment, Chapter R.7a,
(ECHA, 2017a)) and the rest will be extensively biodegraded (due to
ready biodegradability). Thus, discharged concentrations of these
substances into the aqueous compartment are likely to be very low. If
direct/indirect application of the substances occurs (indirect via
sludge application) will occur, the substance will again be rapidly
degraded until ultimate biodegradation. In addition, use information on
this substance as presented in chapter 3.5 of technical dossier, exclude
direct exposure to soil. In accordance with Annex IX, column 2 (9.4) of
Regulation (EC) No. 1907/2006, testing for toxicity to soil
macroorganisms is not required since direct and indirect exposure of the
soil compartment is unlikely. Therefore, no tests on terrestrial
organisms are provided.
Aquatic ecotoxicity data
Acute and chronic aquatic toxicity tests of the substance
Propane-1,2,3-triyl 2-ethylhexanoate (CAS No. 7360-38-5) and the read
across analogue Propane-1,2,3-triyl trisheptanoate (CAS No. 620-67-7) to
fish, invertebrates, algae and microorganisms showed no adverse effects
occurred in the range of the water solubility of the substance (< 0.05
mg/L measured in aqua dest). The obtained results indicate that
Propane-1,2,3-triyl 2-ethylhexanoate is likely to show no toxicity to
soil organisms as well. The Guidance on information requirements and
chemical safety assessment, Chapter R.7c (ECHA, 2017c, p.121)
states: “it will normally not be possible to derive a robust PNEC for
the purposes of a soil screening assessment from acute aquatic toxicity
testing showing no effect. The absence of chronic or long-term effects
in aquatic organisms up to the substance solubility limit, or of acute
effects within the solubility range above 10 mg/L can be used as part of
a Weight of Evidence argument to modify/waive the data requirements of
Annex IX and X.” Based on the available information, toxicity to
terrestrial soil macroorganisms is not expected to be of concern.
After absorption, Propane-1,2,3-triyl 2-ethylhexanoate is expected to be
enzymatically hydrolysed in vivo by the ubiquitary enzyme
carboxylesterase, yielding the corresponding alcohol and 2-ethylhexanoic
acid. QSAR estimations using BCFBAF v3.0 support the expected rapid
biotransformation of this substance with BCF/BAF values of 1.05 L/kg,
respectively (Arnot-Gobas estimation including biotransformation, upper
The metabolism of the hydrolysis products: alcohol (i.e. Glycerol) and
2-ethylhexanoic acid is well established and not of concern in terms of
bioaccumulation (for further information see chapter 5.3 of the
technical dossier).This is also underlined by their low log Kow values
(-1.65 and 2.96, for glycerol and 2-ethylhexanoic acid, respectively;
values calculated using KOWWIN v1.68).
Summarizing, Propane-1,2,3-triyl 2-ethylhexanoate is expected to be
rapidly hydrolyzed to 2-ethylhexanoic acid and Glycerol. Both hydrolysis
products are supposed to be satisfactory metabolized in organisms and
are not bioaccumulative. Therefore, no potential for bioaccumulation is
to be expected.
Propane-1,2,3-triyl 2-ethylhexanoate is unlikely to pose a risk for
terrestrial organisms based on a) the lack of exposure and b) the low
toxicity as expected for this substance for terrestrial organisms based
on metabolism considerations and the lack of adverse effects in aquatic
ecotoxicity tests. Therefore, no tests on terrestrial organisms are
A detailed reference list is provided in the technical dossier (see
IUCLID, section 13) and within the CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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