Propane-1,2,3-triyl 2-ethylhexanoate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given. Lack of details on the test material and limited documentation.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

lack of details on the test material and limited documentation

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Propane-1,2,3-triyl trisheptanoate

EC Number:

210-647-2

EC Name:

Propane-1,2,3-triyl trisheptanoate

Cas Number:

620-67-7

IUPAC Name:

propane-1,2,3-triyl triheptanoate

Test material form:

liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200 ± 20 g
- Fasting period before study: overnight
- Housing: through the observation period of the test, animals were segregated in cages according to sex and dosage group.
- Diet: normal diet (not further specified)
- Water: ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg

Doses:

First experiment (range-finder): 0.5, 1, 2.5 and 5 mL/kg bw
Second experiment: 5 mL/kg bw

No. of animals per sex per dose:

First experiment (range-finder): 1
Second experiment: 5

Control animals:

other: not required

Details on study design:

- Duration of observation period following administration: 7 and 14 days in the first and second experiment, respectively.
- Frequency of observations: animals were observed immediately after dosing and daily thereafter. Any deaths or signs of toxicity were recorded.
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, mortality

Results and discussion

Preliminary study:

No mortality occurred in rats (2 per dose level) administered the test substance at 0.5, 1, 2.5 and 5 mL/kg bw and observed for 7 days.

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 mL/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 4 820 mg/kg bw

Based on:

test mat.

Remarks on result:

other: converted from mL/kg bw based on a density of 0.964 g/mL (Spilker, 2011)

Mortality:

No mortality occurred during the study period.

Clinical signs:

other: No clinical signs of toxicity were observed up to the end of the 14-day observation period.

Applicant's summary and conclusion

Interpretation of results:

other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008